Collin Lab

Directory of Calyptraeid Researchers

Dr. Jon Henry

Jonathan Henry
Professor & Associate Head
Dept. of Cell and Developmental Biology
University of Illinois
601 S. Goodwin Ave.
Urbana, IL 61801
Email: j-henry4@illinois.edu
Web

Our lab is examining developmental events leading to the formation of diverse larval and adult body plans in different marine invertebrates, including a group of protostome phyla collectively referred to as the "Spiralia." The "Spiralia" represent a large group of closely related invertebrate phyla (members of the protostome, "Lophotrochozoa"). Despite the fact that this clade represents nearly 20% of the 30-plus metazoan phyla, relatively little is known of the cellular and molecular mechanisms controlling their development.

Studies point to significant levels of conservation in the functions of a number of transcriptional regulatory networks and cell signaling pathways during development in the Metazoa. Most developmental/molecular studies have been carried out in a relatively small number of model systems, which have been selected for certain experimental advantages. Therefore, the generality of so-called "fundamental" developmental processes within the Spiralia, and the Metazoa in general, is uncertain. Our studies examine the role of key cellular and molecular mechanisms in the establishment of cell fates and axial properties in representatives of the relatively understudied clade, the Spiralia. Our work now focuses on the slipper snail, Crepidula fornicata, as a model system to carry out this research

For the past 7 years my lab has been characterizing the early development of Crepidula fornicata. In collaboration with other labs we have established an embryonic fate map for each cell through the formation of the 4th quartet of micromeres. We have also examined the roles of particular cell-cell interactions and various signaling pathways (e.g., MAPK and beta-catenin) in the establishment of specific cell fates and the dorsoventral axis. More recently we have completed 454 EST sequencing to identify genes expressed during early development, and this information is available at www.life.illinois.edu/henry/crepidula_databases.html.

References:

Henry, J. Q. Perry, K. J. and Martindale, M. Q. (2006). Cell specification and the role of the polar lobe in the gastropod mollusc, Crepidula fornicata. Developmental Biology . 297: 295-307.

Hejnol, A., Martindale, M. Q. and Henry J. Q. (2007). High resolution fate map of the gastropod snail Crepidula fornicata. Origins of ciliary bands, nervous and musculature elements. Developmental Biology 305: 63-76. (research photo also on cover of issue)

Henry, J. Q., Hejnol, A., Perry, K. J. and Martindale, M. Q. (2007). Homology of the ciliary bands of spiralian trochophores and other larvae. Integrat. Compar. Biology. 47: 865-871.

Henry, J. J. and Perry, J. (2008). MAPK activation and the specification of the D quadrant in the gastropod mollusc Crepidula fornicata. Developmental Biology, 313: 181-195.

Henry, J. Q., Collin, R. and Perry, K. J. (2010). The Slipper Snail, Crepidula: An Emerging Lophotrochozoan Model System. The Biological Bulletin. 218: 211-229).

Henry, J. Q., Collin, R. and Perry, K. J. (2010). Methods for Working with the Slipper snail, Crepidula: An Emerging Lophotrochozoan Model System. The Biological Bulletin. (On-line, Peer-reviewed companion to the paper listed above, see www.life.illinois.edu/henry/crepidula_methods.html, see also http://biogeodb.stri.si.edu/bioinformatics/dfm/metas/view/ 38301).

Henry, J. J. and Perry, J. J. and Martindale, M. Q. (2010). ß-catenin and early development in the gastropod, Crepidula fornicata Integrat. Compar. Biology (In Press).

Henry, J. J., Perry, J. J., Fukui, L. and Alvi, N. (2010). Differential Localization of mRNAs During Early Development in the Mollusc, Crepidula fornicata. Integrat. Compar. Biology (In Press).

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